Methanol → HCID 20542789, compound

HRID 615008Notes

Reaction equation

HRID 615008 reaction equation
C([O:3][C:4](=[O:16])[CH2:5][C:6]1[C:7]([CH3:15])=[N:8][N:9]([CH2:12][CH:13]=[CH2:14])[C:10]=1[CH3:11])C.CO.[OH-].[Na+]>O>[CH3:15][C:7]1[C:6]([CH2:5][C:4]([OH:16])=[O:3])=[C:10]([CH3:11])[N:9]([CH2:12][CH:13]=[CH2:14])[N:8]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 54329811HCID 54329811, compound

Product 1

HCID 20542789HCID 20542789, compoundYield 48.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5 grams of 3,5-dimethyl-1-allyl-pyrazol-4-acetic acid-ethyl ester were mixed with 25 milliliters methanol and 10 milliliters water. The mixture was heated to the boiling temperature and held there while 11.3 milliliters 2N aqueous sodium hydroxide were added dropwise at such rate, that the pH of 10 was maintained. The reaction mixture thus obtained was worked up by the procedure described in Example (1b). 2.1 grams 3,5-dimethyl-1-allyl-pyrazol-4-acetic acid melting at 139°-140° C. were obtained representing a yield of 48%.

Workup

  1. temperatureThe mixture was heated to the boiling temperature
  2. additionwere added dropwise at such rate, that the pH of 10
  3. temperaturewas maintained
  4. customThe reaction mixture thus obtained

Sources & evidence

ORD record
ord-8651e456905e431f9af3677e50b3a35c
Source dataset
uspto-grants-1979_03
Patent number
US04146721

Reaction notes

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