Ethyl bromoacetate → HCID 53739683, compound

HRID 615019Notes

Reaction equation

[C:1]1([C:7](=[O:19])[CH2:8][C:9]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:20]([O:22][C:23](=[O:26])[CH2:24]Br)[CH3:21]>>[CH2:20]([O:22][C:23](=[O:26])[CH2:24][CH:8]([C:7](=[O:19])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[C:9](=[O:10])[C:11]1[CH:12]=[CH:13][C:14]([O:17][CH3:18])=[CH:15][CH:16]=1)[CH3:21]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 960691,3-Propanedione, 1-(4-methoxyphenyl)-3-phenyl-

Product 1

HCID 53739683HCID 53739683, compound

Procedure

By a method analogous to that described in Example 28, 1-phenyl-3-(p-methoxyphenyl)-1,3-propanedione was reacted with bromoacetic acid-ethyl ester to form 3-benzoyl-3-p-anisoyl-propionic acid-ethyl ester, which was further reacted with phenylhydrazine to form 1,3-diphenyl-5-(p-methoxyphenyl)-pyrazol-4-acetic acid-ethyl ester, from which was obtained by saponification 1,3-diphenyl-5-(p-methoxyphenyl)-pyrazol-4-acetic acid having a melting point of 160°-163° C.

Sources & evidence

ORD record: ord-67b35f6623854ad3899accca0dc3cc25
Source dataset: uspto-grants-1979_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04146721

Reaction notes

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