Sodium hydride → 3,3-Diacetyl-propionic acid-benzylester

Participants

Reaction Steps

10 grams acetylacetone were reacted with 5 grams of a 50% suspension of sodium hydride in paraffin oil and with 25 grams bromoacetic acid-benzylester in accordance with a procedure analogous to that set out in Example (2b). 3,3-diacetyl-propionic acid-benzylester having a Kp0.005 of 126°-128° C. was obtained. This substance was further reacted with phenylhydrazine by a procedure analogous to that set out in Example (2c). 3,5-dimethyl-1-phenyl-pyrazol-4-acetic acid-benzylester, having a Kp0.001 of 205°-209° C., was obtained in a yield of 51%.

Provenance & Evidence