Sulfuric Acid → 3,5-Dimethyl-1-phenyl-pyrazol-4-acetamide

HRID 615031Notes

Reaction equation

HRID 615031 reaction equation
[CH3:1][C:2]1[C:6]([CH2:7][C:8]#[N:9])=[C:5]([CH3:10])[N:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:3]=1.S(=O)(=O)(O)[OH:18].[OH-].[Na+]>O>[CH3:1][C:2]1[C:6]([CH2:7][C:8]([NH2:9])=[O:18])=[C:5]([CH3:10])[N:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:3]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 137928693,5-Dimethyl-1-phenyl-pyrazol-4-acetonitrile

Product 1

HCID 205427213,5-Dimethyl-1-phenyl-pyrazol-4-acetamideYield 63%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

10 grams 3,5-dimethyl-1-phenyl-pyrazol-4-acetonitrile were added to 40 milliliters concentrated sulfuric acid and the mixture was stirred over night at room temperature. The reaction mixture was poured into a mixture of ice and water and the pH was adjusted to 8 by the addition of aqueous sodium hydroxide. 6.8 grams 3,5-dimethyl-1-phenyl-pyrazol-4-acetamide, melting at 169°-170° C., were obtained, representing a yield of 63%.

Sources & evidence

ORD record
ord-bd3b32bde724476aa311cd2e50f5417c
Source dataset
uspto-grants-1979_03
Patent number
US04146721

Reaction notes

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