HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 615044Generated: October 27, 2026
Epichlorohydrin → 2,3-Epoxypropyl 4-(n-hexadecylamino)benzoate
https://huagongshe.com/reaction/615044
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | Hexamethylphosphoramide | HCID 12679 | — |
| Reactant | Cetaben Sodium | HCID 23703815 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2,3-Epoxypropyl 4-(n-hexadecylamino)benzoate | HCID 13019377 | — |
Reaction Steps
A mixture of 89.0 g of epichlorohydrin, 92.0 g of sodium 4-(n-hexadecylamino)benzoate, and 350 ml of hexamethylphosphoramide is stirred at 105° C. for 5 hours, allowed to cool, and poured into 1.0 liter of water. The white solid is collected by filtration, recrystallized from acetonitrile and then from hexane-methylene chloride to yield 2,3-epoxypropyl 4-(n-hexadecylamino)benzoate, mp 86°-89° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04146546 |
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| Source dataset | uspto-grants-1979_03 |
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| ORD ID | ord-155ac92aee65436a99ae530899e56e17 |
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| Source note | uspto-grants-1979_03 |
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