3-Bromo-1-propanol → 3-Hydroxypropyl 4-(n-hexadecylamino)benzoate

HRID 615051Notes

Reaction equation

Br[CH2:2][CH2:3][CH2:4][OH:5].[CH2:6]([NH:22][C:23]1[CH:31]=[CH:30][C:26]([C:27]([O-:29])=[O:28])=[CH:25][CH:24]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21].[Na+]>>[CH2:6]([NH:22][C:23]1[CH:24]=[CH:25][C:26]([C:27]([O:29][CH2:2][CH2:3][CH2:4][OH:5])=[O:28])=[CH:30][CH:31]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]

Participants

Reactant 2

HCID 123083-Bromo-1-propanol

HCID 23703815Cetaben Sodium

Product 1

HCID 130193793-Hydroxypropyl 4-(n-hexadecylamino)benzoate

Procedure

In the manner described in Example 19, treatment of 3-bromopropanol with sodium 4-(n-hexadecylamino)benzoate affords 3-hydroxypropyl 4-(n-hexadecylamino)benzoate, mp 67°-69° C.

Sources & evidence

ORD record: ord-1e4890f276f742579c3cddac505394ac
Source dataset: uspto-grants-1979_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04146546

Reaction notes

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