Acetone → HCID 135797539, compound

HRID 615098Notes

Reaction equation

HRID 615098 reaction equation
O.[NH2:2][C:3]1[NH:4][C:5]2[CH:11]=[C:10]([CH3:12])[C:9]([CH3:13])=[CH:8][C:6]=2[N:7]=1.[CH3:14][N:15]=[C:16]=[O:17].[CH3:18][C:19]([CH3:21])=O>>[CH3:18][C:19]1([CH3:21])[N:15]([CH3:14])[C:16](=[O:17])[N:4]2[C:3](=[N:7][C:6]3[CH:8]=[C:9]([CH3:13])[C:10]([CH3:12])=[CH:11][C:5]=32)[NH:2]1

Participants

4

Reactant 3

HCID 180AcetoneHCID 12228Methyl IsocyanateHCID 20427211HCID 20427211, compound

Product 1

HCID 135797539HCID 135797539, compound

Procedure

2-Amino-5,6-dimethylbenzimidazole monohydrate, acetone and methyl isocyanate were reacted, conducting the initial condensation and subsequent base hydrolysis of the intermediate 10-N-methylcarbamoyl precursor as described in Example 1. The title compound was recovered and purified by liquid chromatography to give a solid, mp 211° C. (dec.). The confirmatory elemental analysis is shown in Table III.

Workup

  1. customcondensation and subsequent base hydrolysis of the intermediate 10-N-methylcarbamoyl precursor
  2. customThe title compound was recovered
  3. custompurified by liquid chromatography
  4. customto give a solid, mp 211° C. (dec.)

Sources & evidence

ORD record
ord-24dba402f86b4fd89c243266d0c62ec0
Source dataset
uspto-grants-1985_02
Patent number
US04497650

Reaction notes

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