反应详情

A mixture of benzyl 2-[3-phenoxyacetamido-4-(2,2,2-trichloroethoxycarbonylthio)-2-oxo-1-azetidinyl]-2-azidoacetate (2.856 g.) and 10% palladium on carbon (600 mg.) in formic acid (27 ml.) was stirred at room temperature under hydrogen atmosphere. After stirring for an hour, to the mixture wass added 5% palladium on carbon (600 mg.) in formic acid (8 ml.) and stirred under hydrogen atmosphere for additional 2.5 hours. The resultant mixture was filtered through a pad of Celite and the filter cake was washed with methylene chloride. The filtrate and washings were combined and concentrated in vacuo to a volume of 15 ml. A part of this concentrate was evaporated to dryness to give benzyl 2-[3-phenoxyacetamido-4-(2,2,2-trichloroethoxycarbonylthio)-2-oxo-1-azetidinyl]-2-aminoacetate.

1. stirringAfter stirring for an hour, to the mixture
2. stirringstirred under hydrogen atmosphere for additional 2.5 hours
3. filtrationThe resultant mixture was filtered through a pad of Celite
4. washthe filter cake was washed with methylene chloride
5. concentrationconcentrated in vacuo to a volume of 15 ml
6. customA part of this concentrate was evaporated to dryness