HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-PYRIDINECARBOXALDEHYDE, 1-OXIDE
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | HCID 70489168 | HCID 70489168 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-PYRIDINECARBOXALDEHYDE, 1-OXIDE | HCID 556031 | — |
Reaction Steps
Analogously to the process described in Example 1 there is obtained from 22.5 g of pyridine-2-carboxaldehyde-1-oxide, 37 ml of ethyl acetoacetate and 14.5 ml of 30% aqueous ammonia in 29 ml of absolute ethanol, 2,6-dimethyl-4-(1-oxido-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid dietyl ester which, after recrystallisation from 250 ml of acetonitrile, melts at 198°-200°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04497808 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-98f24e04cf44442a864f20efdb7b4024 |
| Source note | uspto-grants-1985_02 |