HCID 13309023, compound → HCID 13309024, compound

Participants

Reaction Steps

A suspension of diethyl N-[3-fluoro-2-(4-pyridyl)-6-pyridyl]aminomethylenemalonate (11.5 g) in 120 ml of Dowtherm A was heated to reflux for 10 minutes and then cooled to room temperature. The resulting solid was filtered off. The filtrate was heated to reflux for 10 minutes and the solid was collected. The combined solid was washed successively with ethanol and ether to give ethyl 6-fluoro-1,4-dihydro-4-oxo-7-(4-pyridyl)-1,8-naphthyridine-3-carboxylate (7.2 g, m.p. 280°-285° C.).

Provenance & Evidence