Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 5-Fluorouracil | HCID 3385 | — |
| Reactant | 5-Isocyanato-1,2,3-trimethoxybenzene | HCID 517766 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10497271 | HCID 10497271 | 47.2% |
Reaction Steps
A mixture of 3.9 g of 5-fluorouracil, 6.27 g of 3, 4, 5-trimethoxyphenylisocyanate and 15 ml of pyridine was heated at 90° C. for 2 hr and, after evaporating pyridine, 100 ml of dichloromethane and 200 ml of hydrochloric acid water were added to it. The insoluble substance produced was combined with the substance dissolved in the dichloromethane. The combined substances were washed with water and then with ethanol, and 4.8 g of 1-(3, 4, 5-trimethoxyphenylcarbamoy)-5-fluorouracil (melting point: 168°-170° C.) was obtained (Compound No. 6). NMR: 3.76 (3H s OCH3) 3.84 (6H s OCH3) 6.64-7.0 (2H b C6H2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04497815 |
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| Source dataset | uspto-grants-1985_02 |
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| ORD ID | ord-ab67e4ab0ed64bf9a7b537de97bb71fd |
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| Source note | uspto-grants-1985_02 |
|---|
