Ammonia → HCID 12926124, compound

HRID 615157Notes

Reaction equation

HRID 615157 reaction equation
Br.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[N:11]=[C:12]2[N:16]([CH:17]=1)[C:15]1[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=1[S:13]2.N>C(Cl)(Cl)Cl>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[N:11]=[C:12]2[N:16]([CH:17]=1)[C:15]1[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=1[S:13]2

Participants

4

Reactant 2

HCID 222AmmoniaHCID 12926125HCID 12926125, compound

Product 1

HCID 12926124HCID 12926124, compoundYield 81.6%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

Then, 3 g of the hydrobromide was added to a mixture of 50 ml of chloroform and 20 ml of 20% aqueous ammonia and after stirring the mixture for 20 minutes at room temperature, the chloroform layer formed was recovered. The chloroform layer obtained was washed with water, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to form white solid materials, which were recrystallized from toluene-n-hexane to provide 1.9 g of 2-(o-methoxyphenyl)imidazo[2,1-b]-benzothiazole.

Workup

  1. customwas recovered
  2. customThe chloroform layer obtained
  3. washwas washed with water
  4. dry with materialdried with anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customto form white solid materials, which
  7. customwere recrystallized from toluene-n-hexane

Sources & evidence

ORD record
ord-7d6129dd4941419bb439d9b38537dc74
Source dataset
uspto-grants-1985_02
Patent number
US04497817

Reaction notes

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