Acetic Acid → HCID 12926122, compound

HRID 615160Notes

Reaction equation

HRID 615160 reaction equation
[OH-].[K+].C([O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]3[N:19]([CH:20]=2)[C:18]2[CH:21]=[CH:22][CH:23]=[CH:24][C:17]=2[S:16]3)=[CH:9][CH:8]=1)(=O)C.C(O)(=O)C>CO>[OH:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[N:14]=[C:15]3[N:19]([CH:20]=2)[C:18]2[CH:21]=[CH:22][CH:23]=[CH:24][C:17]=2[S:16]3)=[CH:11][CH:12]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 14797Potassium HydroxideHCID 12926116HCID 12926116, compound

Product 1

HCID 12926122HCID 12926122, compoundYield 86.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a solution of 2.5 g of potassium hydroxide in 90% methanol was suspended 2 g of 2-(p-acetoxyphenyl)imidazo-[2,1-b]benzothiazole and the suspension was stirred for one hour at 40°-50° C., thereby the additive was completely dissolved. Then, 3 ml of acetic acid was gradually added dropwise to the reaction mixture with stirring, thereby crystals precipitated. The crystals were recovered by filtration, washed with water and then methanol, and dried to provide 1.5 g of 2-(p-hydroxyphenyl)imidazo[2,1-b]benzothiazole.

Workup

  1. dissolutionthe additive was completely dissolved
  2. stirringwith stirring
  3. customcrystals precipitated
  4. filtrationThe crystals were recovered by filtration
  5. washwashed with water
  6. dry with materialmethanol, and dried

Sources & evidence

ORD record
ord-1e4beb61d7e241998e071033859185bf
Source dataset
uspto-grants-1985_02
Patent number
US04497817

Reaction notes

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