Methanol → HCID 12926123, compound

HRID 615161Notes

Reaction equation

HRID 615161 reaction equation
[OH-].[K+].CO.C[O:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]3[N:21]([CH:22]=2)[C:20]2[CH:23]=[CH:24][CH:25]=[CH:26][C:19]=2[S:18]3)=[CH:11][CH:10]=1)=[O:8]>C(O)(=O)C>[C:7]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]3[N:21]([CH:22]=2)[C:20]2[CH:23]=[CH:24][CH:25]=[CH:26][C:19]=2[S:18]3)=[CH:11][CH:10]=1)([OH:8])=[O:6]

Participants

5

Reactant 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 12926118HCID 12926118, compound

Product 1

HCID 12926123HCID 12926123, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a mixture of 15 ml of an aqueous solution of 20% potassium hydroxide and 50 ml of methanol was added 2.2 g of 2-(p-methoxycarbonylphenyl)imidazo[2,1-b]benzothiazole and the mixture was refluxed for 30 minutes. After the reaction was over, 4 ml of acetic acid was added to the reaction mixture and the crystals which had formed were recovered by filtration, washed successively with water, methanol and then ethanol, and dried to provide 1.7 g of 2-(p-carboxyphenyl)imidazo[2,1-b]benzothiazole.

Workup

  1. temperaturethe mixture was refluxed for 30 minutes
  2. additionwas added to the reaction mixture
  3. customthe crystals which had formed
  4. filtrationwere recovered by filtration
  5. washwashed successively with water, methanol
  6. dry with materialethanol, and dried

Sources & evidence

ORD record
ord-9a2089b269b044fdaac9767512447432
Source dataset
uspto-grants-1985_02
Patent number
US04497817

Reaction notes

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