Iodine → HCID 12831509, compound

HRID 615166Notes

Reaction equation

HRID 615166 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[N:14]([CH:15]=2)[C:13]2[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=2[S:11]3)=[CH:4][CH:3]=1.C(=O)([O-])O.[K+].[I:25]I>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]3[N:14]([C:15]=2[I:25])[C:13]2[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=2[S:11]3)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 807IodineHCID 516893Potassium BicarbonateHCID 667714HCID 667714, compound

Product 1

HCID 12831509HCID 12831509, compoundYield 83.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In 100 ml of methylene chloride was dissolved 2 g of 2-(p-chlorophenyl)imidazo[2,1-b]benzothiazole and after adding thereto 20 ml of an aqueous 10% potassium hydrogencarbonate solution and 1.8 g of iodine, the mixture was stirred overnight vigorously at room temperature. The crystals which formed were recovered by filtration and recrystallized from a mixture of methylcellosolve and water to provide 2.4 g of 2-(p-chlorophenyl)-3-iodoimidazo[2,1-b]benzothiazole.

Workup

  1. additionafter adding
  2. customThe crystals which formed
  3. filtrationwere recovered by filtration
  4. customrecrystallized from a mixture of methylcellosolve and water

Sources & evidence

ORD record
ord-b6256c5dba224947a5577107a453d7c7
Source dataset
uspto-grants-1985_02
Patent number
US04497817

Reaction notes

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