反应详情

6.8 g of chromium(VI) oxide were added in portions to a boiling solution of 41.8 g (100 mmols) of isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate in 160 ml of glacial acetic acid. The mixture was then heated under reflux for a further 30 minutes and, after cooling down, poured into ammoniacal ice-water. The mixture was extracted with chloroform and the extracts, after drying over sodium sulphate, were evaporated in vacuo. 35.9 g (86% of theory) of an oil resulted.

1. temperatureThe mixture was then heated
2. temperatureunder reflux for a further 30 minutes
3. temperatureafter cooling down
4. extractionThe mixture was extracted with chloroform
5. dry with materialthe extracts, after drying over sodium sulphate
6. customwere evaporated in vacuo
7. custom35.9 g (86% of theory) of an oil resulted