1-Propanol → HCID 70479025, compound

Participants

Reaction Steps

A solution of methyl 2β,3α-dihydroxy-11α-(3-methylbutylamino)-5α-androstane-17β-carboxylate (437 mg) in propan-1-ol (30 ml) was heated at 100° C. with conc. sulphuric acid (0.2 ml) for 40 h. The cooled mixture was concentrated by evaporation and the residue diluted with water (150 ml) and brought to pH 10 by the addition of 0.88 ammonia solution. The suspension was extracted with ethyl acetate (3×) and the extracts washed with brine, dried and evaporated to give a solid. This was crystallised from ethyl acetate to give the title compound (70 mg), m.p. 140°-142° C., [α]D +17.2°.

Provenance & Evidence