Sulfuric Acid → HCID 70479527, compound

Participants

Reaction Steps

A solution of propyl 2β,3α-dihydroxy-11α-(3-methylbutylamino)-5α-androstane-17β-carboxylate (100 mg) in methanol (10 ml) was heated at 100° C. with concentrated sulphuric acid (0.2 ml) for 48 h. The cooled mixture was evaporated, the residue brought to pH 10 by the addition of 0.88 ammonia solution and extracted with ethyl acetate (3×). The extracts were washed with water, dried and evaporated to give the title compound (80 mg), [α]D +22.4°.

Provenance & Evidence