HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,3-Epoxypropoxy)-4-(2-methoxyethoxy)benzene → 1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-[4-(2-methoxyethoxy)phenoxy]-propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,3-Epoxypropoxy)-4-(2-methoxyethoxy)benzene | HCID 12621549 | — |
| Reactant | 5-(2-Benzylaminopropoxy)salicylamide | HCID 13754334 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-[4-(2-methoxyethoxy)phenoxy]-propan-2-ol | HCID 13754335 | — |
Reaction Steps
A solution of 10.2 g of 1-(2,3-epoxypropoxy)-4-(2-methoxyethoxy)benzene and 11.0 g of 5-[2-(benzylamino)-propoxy]salicylamide in 200 ml of isopropanol is refluxed for 24 hours. By concentration of the solution by evaporation, crude 1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-[4-(2-methoxyethoxy)phenoxy]-propan-2-ol is obtained as an oil which is used in its crude state for debenzylation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04497813 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-943dba6da96f4f08b68ce8ac9d39c937 |
| Source note | uspto-grants-1985_02 |