HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Propanol, 1-amino-3-[2-(2-propenyloxy)phenoxy]- → 1-(2-Allyloxyphenoxy)-3-[2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino]propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Propanol, 1-amino-3-[2-(2-propenyloxy)phenoxy]- | HCID 12226588 | — |
| Reactant | 5-(2-Bromoethoxy)salicylamide | HCID 13754420 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-(2-Allyloxyphenoxy)-3-[2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino]propan-2-ol | HCID 13754367 | — |
Reaction Steps
A mixture of 6.5 g of 5-(2-bromoethoxy)salicylamide and 8.9 g of 1-(2-allyloxyphenoxy)-3-aminopropan-2-ol is melted in an oil bath at 100° and stirred for 1 hour using a magnetic stirrer. The working up is carried out analogously to Example 11 and yields 1-(2-allyloxyphenoxy)-3-[2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino]-propan-2-ol having a melting point of 147°-148° (from isopropanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04497813 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-b082e26b93584288b8e84675f4830f95 |
| Source note | uspto-grants-1985_02 |