反应详情

59.6 g of N-(2-hydroxyethyl)-N'-(2-benzyloxybenzyl)-urea are dissolved in 600 ml of methanol and hydrogenated in the presence of 6 g of Pd/C-catalyst (5%). After 2 hours the hydrogenation ceases. The catalyst is suction-filtered, and the filtrate concentrated by evaporation in vacuo. The residue is recrystallised from 350 ml of ethyl acetate; the pure product melts at 100°-101°.

1. filtrationThe catalyst is suction-filtered
2. concentrationthe filtrate concentrated by evaporation in vacuo
3. customThe residue is recrystallised from 350 ml of ethyl acetate