1-(2,3-Epoxypropoxy)-4-(2-methoxyethoxy)benzene → 1-[N-[2-(3-carbamoyl-2-hydroxyphenoxy)ethyl]benzylamino]-3-[4-(2-methoxyethoxy)-phenoxy]propan-2-ol
Reaction equation
[O:1]1[CH2:16][CH:2]1[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][O:14][CH3:15])=[CH:7][CH:6]=1.[CH2:17]([NH:24][CH2:25][CH2:26][O:27][C:28]1[CH:36]=[CH:35][CH:34]=[C:30]([C:31]([NH2:33])=[O:32])[C:29]=1[OH:37])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:31]([C:30]1[C:29]([OH:37])=[C:28]([CH:36]=[CH:35][CH:34]=1)[O:27][CH2:26][CH2:25][N:24]([CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[CH2:16][CH:2]([OH:1])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][O:14][CH3:15])=[CH:7][CH:6]=1)(=[O:32])[NH2:33]Participants
3
Procedure
By reacting 2.5 g of 1-(2,3-epoxypropoxy)-4-(2-methoxyethoxy)benzene with 2.9 g of crude 3-(2-benzylaminoethoxy)salicylamide obtained according to Example (25c), analogously to Example (4a), 1-[N-[2-(3-carbamoyl-2-hydroxyphenoxy)ethyl]benzylamino]-3-[4-(2-methoxyethoxy)-phenoxy]propan-2-ol is obtained as an oil which is further processed in this state.
Workup
- customobtained
Sources & evidence
- ORD record
- ord-4aa83224acc847e8ae2819624f1dcf69
- Source dataset
- uspto-grants-1985_02
- Patent number
- US04497813
Reaction notes
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