Triethylamine → L-Tryptophan, methyl ester

Participants

Reaction Steps

The tryptophan methylester hydrochloride thus obtained was suspended in 1 liter of ethyl acetate and 100 ml of triethylamine was added thereto. The mixture was allowed to react for 1 hour while vigorously stirring. The insoluble matter (i.e. triethylamine hydrochloride) was filtered off and the filtrate was washed with a small amount of water. Thereafter, the solvent was distilled off to obtain 40 g of oily tryptophan methylester.

Provenance & Evidence