HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2-{4-[4-(Trifluoromethyl)phenoxy]phenoxy}propanoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Trifop | HCID 181206 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-{4-[4-(Trifluoromethyl)phenoxy]phenoxy}propanoyl chloride | HCID 12906015 | — |
Reaction Steps
Oxalyl chloride (1.56 g, 1.1 ml, 12.32 mmol) is added to a stirring solution of 2-[4-(4-trifluoromethylphenoxy)phenoxy]propionic acid (2.00 g, 6.16 mmol), dimethylformamide (DMF; 4 drops) and ether (50 ml). The mixture is stirred at RT for 3 hours. Insoluble material is filtered off and solvent is removed in vacuo to give 2-[4-(4-trifluoromethylphenoxy)phenoxy]propionic acid chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04497965 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-b22259dbd0674c5cbab84b9151c284b3 |
| Source note | uspto-grants-1985_02 |