HCID 178448355, compound → HCID 178448356, compound

Participants

Reaction Steps

H-Ser-Val-Arg-Ser-Lys-Lys-Thr-Ala-Lys-Trp(CHO)-Asn-OH (2) (965 mg) was dissolved in 0.1M ammonium hydrogen carbonate (90 ml) and the solution was stirred at 37°-38° C. for 24 hours, followed by addition of 0.1M ammonium hydrogen carbonate (4.5 g). The mixture was further stirred at 43° C. for 24 hours and then concentrated. The concentrate was chromatographed on a Sephadex G-25 column (3.2×65 cm), elution being carried out with 1N acetic acid, to give crude H-Ser-Val-Arg-Ser-Lys-Lys-Thr-Ala-Lys-Trp-Asn-OH (3).

Provenance & Evidence