Hydrochloric Acid → HCID 20427611, compound

Participants

Reaction Steps

8.8 g 1-(3-bromopropyl)-2-ethylthio-5-oxo-4,4-diphenyl-2-pyrroline-3-carbonitrile and 3.0 g ethylamine are stirred for two days at room temperature in 300 ml dioxan. The solvent is removed on a Rotavapor and the residue partitioned between chloroform and dil. sodium bicarbonate solution. The organic phase is evaporated and the residue chromatographed on silica gel with toluene/ethanol 10+1 as elution agent. The base so obtained is converted in ethanolic solution into the corresponding hydrochloride by mixing with ethereal hydrochloric acid solution. One obtains 1.0 g of colorless crystals of mp 173°-174° C., decomp.

Provenance & Evidence