Benzyl Chloride → HCID 13387947, compound

Participants

Reaction Steps

A mixture of 10.0 g (0.05 mole) of 1-[5-methyl-2-(3-pyridinyl)-1H-imidazol-4-yl]ethanone, 13 ml (0.1+ mole) of benzyl chloride, 10 ml (0.05+ mole) of N,N-diisopropylethylamine and 250 ml of dioxane was stirred at reflux for 18 hours. The resulting precipitate was collected by filtration of the hot mixture, washed free of color with tetrahydrofuran, then dried in vacuo at 100° C. and gave 12.2 g of the desired product as a yellow solid, mp 230°-232° C.

Provenance & Evidence