Hydroxyamine hydrochloride → 1-[5-Methyl-2-(3-methyl-4-pyridinyl)-1H-imidazol-4-yl]ethanone oxime hydrate

Participants

Reaction Steps

To a 1.0 g (0.005 mole) amount of 1-[5-methyl-2-(3-methyl-4-pyridinyl)-1H-imidazol-4-yl]ethanone (prepared as described in Example 27) dissolved in 200 ml of boiling water, were added 1.0 g (0.012 mole) of sodium acetate and 0.7 g (0.01 mole) of hydroxylamine hydrochloride. The mixture was stirred and heated for 3 hours, then cooled at room temperature. The resulting precipitate was collected by filtration and when dried at 60° C. for 18 hours gave 0.6 g of the desired product as its hydrate, a yellowish powder, mp 195°-197° C. (dec.).

Provenance & Evidence