Potassium Hydroxide → HCID 13387896, compound

HRID 615333Notes

Reaction equation

HRID 615333 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:17])[C:7]([C:12]([O:14]CC)=[O:13])=[CH:8][NH:9]2)=[C:4](NCCCC=O)[C:3]=1[F:24].[OH-].[K+].[K]>C(O)C>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:17])[C:7]([C:12]([OH:14])=[O:13])=[CH:8][N:9]2[NH:9][CH2:8][CH2:7][CH3:6])=[CH:4][C:3]=1[F:24]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 5462222PotassiumHCID 86739913HCID 86739913, compound

Product 1

HCID 13387896HCID 13387896, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7-Chloro-6-fluoro-1,4-dihydro-4-oxo-1-propylamino-3-quinolinecarboxylic acid [VI; lower-alkyl=(CH2)2CH3 ] was prepared from 10.5 g of ethyl 7-chloro-6-fluoro-5-[(formyl)propylamino]-1,4-dihydro-4-oxo-3-quinolinecarboxylate (Preparation 3C) and 4.4 g of 85% potassium hydroxide in ethanol solution according to the procedure described above in Preparation 4B. There was obtained 5.7 g of product in the form of its potassium salt hemihydrate, m.p. 267° C. (decompn.).

Sources & evidence

ORD record
ord-a2334f0e5fd54e988064f5bcbb412af6
Source dataset
uspto-grants-1985_02
Patent number
US04499091

Reaction notes

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