Thiomorpholine → HCID 13387920, compound

HRID 615335Notes

Reaction equation

HRID 615335 reaction equation
Cl[C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:17])[C:7]([C:14]([OH:16])=[O:15])=[CH:8][N:9]2[NH:12][CH3:13])=[CH:4][C:3]=1[F:18].[NH:19]1[CH2:24][CH2:23][S:22][CH2:21][CH2:20]1>N1C=CC=CC=1>[F:18][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:2]=1[N:19]1[CH2:24][CH2:23][S:22][CH2:21][CH2:20]1)[N:9]([NH:12][CH3:13])[CH:8]=[C:7]([C:14]([OH:16])=[O:15])[C:6]2=[O:17]

Participants

4

Reactant 2

HCID 67164ThiomorpholineHCID 30212917-Chloro-6-fluoro-1,4-dihydro-1-(methylamino)-4-oxoquinoline-3-carboxylic acid

Product 1

HCID 13387920HCID 13387920, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

6-Fluoro-1,4-dihydro-1-methylamino-4-oxo-7-(4-thiomorpholinyl)-3-quinolinecarboxylic acid [I; R=CH3NH, R"=H, Z=N=4-thiomorpholinyl] was prepared from 3.5 g of 7-chloro-6-fluoro-1,4-dihydro-1-methylamino-4-oxo-3-quinolinecarboxylic acid (Preparation 4A) and 6.5 ml of thiomorpholine in 80 ml of pyridine according to the procedure of Example 1. There was obtained 2 g of product, pale yellow solid, m.p. 260°-261° C. when recrystallized from dimethylformamide.

Sources & evidence

ORD record
ord-13b8c8cb180040988ffed3be1788c946
Source dataset
uspto-grants-1985_02
Patent number
US04499091

Reaction notes

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