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HRID615339

反应详情

EQUATION

反应方程式

HRID 615339 的结构方程式

REACTANTS

反应物

3
结构：C[C@H](NC(=O)OC(C)(C)C)C(=O)O
HCID85082

L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-

C8H15NO4

结构：C[C@H](N)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1.Cl
HCID13034412

未命名化合物

结构：C[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1
HCID13068139

N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl-L-proline phenylmethyl ester

C20H28N2O5

PRODUCTS

生成物

1
结构：C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1
HCID15289361

未命名化合物

收率 36.5%

PROCEDURE

实验过程

Boc-Ala-OH (11.5 g, 48.4 mmoles) was coupled to H-AlaPro-OBzl·HCl (14.9, 47.8 mmoles) by procedures substantially similar to those described above for the preparation of Boc-AlaPro-OBzl, yielding a foam, 22 g. This product crystallized from ethyl acetate to yield Boc-AlaAlaPro-OBzl (7.8 g, mp 120°-121°) in the first crop and 11.1 g (mp 111°-117°) in a second crop. First crop-Anal. Calcd. for C23H33N3O6 (mp 120°-121°): C=61.71%, H=7.45%, N=9.39%. Found: C=61.74%, H=7.56%, and N=9.46%.

WORKUP

后处理

  1. customyielding a foam, 22 g
  2. customThis product crystallized from ethyl acetate