Pimeloyl chloride → HCID 12837236, compound

Participants

Reaction Steps

To a stirred solution of (4R)-2-(3-nitrophenyl-4-thiazolidinecarboxylic acid (5.1 g) in 1M sodium carbonate (40 ml), heptanedioyl dichloride (2.1 g) was added dropwise under ice-cooling. The reaction mixture was stirred for 1 hour at the same temperature, and the separated crystals were filtered to give 4.7 g (69%) of the titled compound as disodium salt: mp 111°-113° C. (dec.) (water); [α]D25 +88.2° (c=0.5, methanol). IR (nujol, cm-1): 1635 (CON), 1585 (COO-), 1520 and 1355 (NO2), 1095, 730. TLC: Rf value* 0.28.

Provenance & Evidence