Acetic Acid → 6-(1-Methylethyl)amino-2-benzothiazolesulfonamide

Participants

Reaction Conditions

Reaction Steps

Sodium borohydride (378 mg, 0.01 mole) and 6-amino-2-benzothiazolesulfonamide (459 mg, 0.002 mole) are ground together, then added very slowly to a mixture of glacial acetic acid (5 ml) and acetone (5 ml) with stirring under nitrogen at 20° C. After vigorous evolution of hydrogen, the reaction mixture is stirred at 20° C. for 2 hrs, treated with H2O, filtered, made basic with 10N NaOH solution, then neutralized with aqueous HCl to give 6-(1-methylethyl)amino-2-benzothiazolesulfonamide.

Provenance & Evidence