HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium cyanoborohydride → 4-{[2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl]amino}piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 13121298 | HCID 13121298 | — |
| Reactant | Piperidin-2-one--hydrogen chloride (1/1) | HCID 20088740 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-{[2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl]amino}piperidine | HCID 20427768 | — |
Reaction Steps
Fifty g of [2-(1,4-benzodioxan-2-yl)-2-hydroxyethyl]amine and 85 g of piperidone HCl (ALDRICH) are dissolved in 1000 ml of ethanol. Sodium cyanoborohydride (75 g) is added, and after stirring at ambient conditions overnight (about 16 hr) the mixture is cooled and evaporated. The product is recovered by extraction with methylene chloride to yield 4-{[2-(1,4-benzodioxan-2-yl)-2-hydroxyethyl]amino}piperidine. This material is of sufficient purity to use in this invention.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04499100 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-dd716794465647778e632ca76c0d1fa6 |
| Source note | uspto-grants-1985_02 |