HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloride → 4-{[2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl]amino}-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloride | HCID 312 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 13121298 | HCID 13121298 | — |
| Reactant | 1-[(2,6-Dimethylphenyl)aminocarbonylmethyl]-4-piperidone | HCID 13393353 | — |
| Product | 4-{[2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl]amino}-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperidine | HCID 13393356 | — |
Reaction Steps
Substituting into the procedure of Example 1, 1-[(2,6-dimethylphenyl)aminocarbonylmethyl]-4-piperidone for the corresponding chloride and [2-(1,4-benzodioxan-2-yl)-2-hydroxyethyl]amine or amine hydrochloride, rather than the corresponding piperidine and adding 75 g of sodium cyanoborohydride, one obtains 4-{[2-(1,4-benzodioxan-2-yl)-2-hydroxyethyl]amino}-1-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperidine compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04499100 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-a5ed76f27e38421e91d30b6d95782757 |
| Source note | uspto-grants-1985_02 |