HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylamine → 1-(3-Chlorophenyl)-N,N-diethylisoquinoline-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 1-(3-Chlorophenyl)isoquinoline-3-carboxylic acid | HCID 13272389 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 1-(3-Chlorophenyl)-N,N-diethylisoquinoline-3-carboxamide | HCID 13272364 | 71.4% |
Reaction Steps
Operations are carried out as for Example 7, starting with 1.7 g of 1-(3-chlorophenyl) isoquinoline 3-carboxylic acid, 0.69 g of triethylamine, 0.74 g of ethyl chloroformate and 0.56 g of diethylamine in 60 ml of chloroform. 1.45 g of N,N-diethyl 1-(3-chlorophenyl) isoquinoline 3-carboxamide melting at 116° C., are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04499094 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-ab0b9e72187949fc9176c618ed1c9862 |
| Source note | uspto-grants-1985_02 |