HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylamine → N,N-Diethyl-1-(4-methylphenyl)isoquinoline-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 1-(4-Methylphenyl)isoquinoline-3-carboxylic acid | HCID 13272390 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | N,N-Diethyl-1-(4-methylphenyl)isoquinoline-3-carboxamide | HCID 13272365 | 53.7% |
Reaction Steps
Operations are carried out as for Example 7, starting from 5 g of 1-(4-methylphenyl) isoquinoline 3-carboxylic acid, 2.18 g of triethylamine, 2.39 g of ethyl chloroformate and 1.83 g of diethylamine in 190 ml of chloroform. 3.25 g of N,N-diethyl 1-(4-methylphenyl) isoquinoline 3-carboxamide melting at 113° C., are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04499094 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-f4e4ff75bc4249a397f6b34a6a94c111 |
| Source note | uspto-grants-1985_02 |