HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-Isoquinolinecarboxamide, 1-(2-chlorophenyl)-N,N-dipropyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Dipropylamine | HCID 8902 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 3-Isoquinolinecarboxylicacid, 1-(2-chlorophenyl)- | HCID 11000554 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3-Isoquinolinecarboxamide, 1-(2-chlorophenyl)-N,N-dipropyl- | HCID 11057656 | 76.2% |
Reaction Steps
Operations are carried out as for Example 7, starting from 1.42 g of 1-(2-chlorophenyl) isoquinoline 3-carboxylic acid, 0.58 g of triethylamine, 0.62 g of ethyl chloroformate and 0.66 g of N-propyl propylamine in 50 ml of chloroform. 1.40 g of N,N-dipropyl 1-(2-chloro phenyl) isoquinoline 3-carboxamide, melting at 101° C., are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04499094 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-7dd1cd01cc0444419ddd184d7320cb67 |
| Source note | uspto-grants-1985_02 |