HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylamine → N,N-Diethyl-1-(3-fluorophenyl)isoquinoline-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 1-(3-Fluorophenyl)isoquinoline-3-carboxylic acid | HCID 13272391 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | N,N-Diethyl-1-(3-fluorophenyl)isoquinoline-3-carboxamide | HCID 13272367 | 116.8% |
Reaction Steps
Operations are carried out as for Example 7, starting from 1.32 g of 1-(3-fluoro phenyl) isoquinoline 3-carboxylic acid, 0.57 g of triethylamine, 0.62 g of ethyl chloroformate, and 0.47 g of diethylamine in 50 ml of chloroform. 1.86 g of N,N-diethyl 1-(3-fluoro phenyl) isoquinoline 3-carboxamide, melting at 92° C., are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04499094 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-c75bf260050d45b5845ec571398d713c |
| Source note | uspto-grants-1985_02 |