HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylamine → 1-(4-Chlorophenyl)-N,N-diethylisoquinoline-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 1-(4-Chlorophenyl)isoquinoline-3-carboxylic acid | HCID 13272396 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 1-(4-Chlorophenyl)-N,N-diethylisoquinoline-3-carboxamide | HCID 13272381 | 45.9% |
Reaction Steps
Operations are carried out as for Example 7, starting from 2.83 g of 1-(4-chloro phenyl) isoquinoline 3-carboxylic acid, 1.15 g of triethylamine, 1.24 g of ethyl chloroformate and 0.95 of diethylamine in 100 ml of chloroform. 1.55 g of N,N-diethyl 1-(4-chloro phenyl) isoquinoline 3-carboxamide, melting at 122° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04499094 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-214d5047edf34654ad39ef2604002392 |
| Source note | uspto-grants-1985_02 |