HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → N-(Butan-2-yl)-N-methyl-4-phenylquinazoline-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | N-Methyl-2-butanamine | HCID 111026 | — |
| Reactant | 4-Phenylquinazoline-2-carboxylic acid | HCID 3738719 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-(Butan-2-yl)-N-methyl-4-phenylquinazoline-2-carboxamide | HCID 13272357 | — |
Reaction Steps
Operations are carried out as for Example 19, starting from 2.5 g of 4-phenyl quinazoline 2-carboxylic acid, 10 ml of thionyl chloride, 25 ml of toluene and 10 ml of N-methyl 2-butanamine. 2.2 g of N-methyl N-(1-methyl propyl) 4-phenyl quinazoline 2-carboxamide, melting at 128° C., are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04499094 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-0ae973724c9d40e98f8c2d1a94701f8d |
| Source note | uspto-grants-1985_02 |