HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2(S)-ethyl 1-[(1-phenyl 3-isoquinolyl) carbonyl]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 1-Phenylisoquinoline-3-carboxylic acid | HCID 407896 | — |
| Reactant | (S)-2-Ethylpiperidine | HCID 5287472 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2(S)-ethyl 1-[(1-phenyl 3-isoquinolyl) carbonyl]piperidine | HCID 24842683 | 86.8% |
Reaction Steps
Operations are carried out as for Example 7, starting from 2.5 g of 1-phenyl isoquinoline 3-carboxylic acid, 1.15 g of triethylamine, 1.24 g of ethyl chloroformate and 1.2 g of 2(S)-ethyl piperidine in 100 ml of toluene. After chromatography, 3 g of 2(S)-ethyl 1-[(1-phenyl 3-isoquinolyl) carbonyl]piperidine in the form of oil are obtained. αD23 =-2.4° (2% in ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04499094 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-134466a4684c4fd39a4f95e8705478d4 |
| Source note | uspto-grants-1985_02 |