Acetyl chloride → Benzoic acid, 3-methoxy-4-methyl-, methyl ester

Participants

Reaction Steps

A solution of 6.0 g (36.1 mmoles) of 3-methoxy-4-methylbenzoic acid in 120 ml of anhydrous MeOH was treated with 6 ml of acetyl chloride and stirred at room temperature for 36 hours. The MeOH was evaporated in vacuo followed by addition and evaporation of two 100 ml portion of methanol to give 6.34 g of methyl 3-methoxy-4-methylbenzoate colorless oil. This was carried through steps analogous to those in Example 1, steps b., c. and d.

Provenance & Evidence