4-Cyanobenzaldehyde → N-{3-[N-(3-aminopropyl)-N-metylamino]propyl}-2-(p-chlorophenyl)ethylamine trihydrochloride

Participants

Role	Name	HCID	Charge
Reactant	4-Cyanobenzaldehyde	HCID 66042	—
Reactant	2-(4-Chlorophenyl)acetaldehyde	HCID 11412502	—
Reactant	N-{3-[N-(3-aminopropyl)-N-methylamino]propyl}-p-cyanobenzylamine trihydrochloride	HCID 20407117	—
Product	N-{3-[N-(3-aminopropyl)-N-metylamino]propyl}-2-(p-chlorophenyl)ethylamine trihydrochloride	HCID 20407063	51%

Reaction Steps

In a similar manner to that described above, N-{3-[N-(3-aminopropyl)-N-methylamino]propyl}-p-cyanobenzylamine trihydrochloride (81% yeild) and N-{3-[N-(3-aminopropyl)-N-metylamino]propyl}-2-(p-chlorophenyl)ethylamine trihydrochloride (51% yield) were obtained from p-cyanobenzaldehyde and p-chlorophenylacetaldehyde, respectively. The physicochemical properties of these compounds were as shown in Table 8.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04500452
Source dataset	uspto-grants-1985_02
ORD ID	ord-7943669392fb4da49f80ac4c46fdf4b3
Source note	uspto-grants-1985_02