Pyridine → HCID 57067061, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of pyridine (124 μl) and trifluoromethanesulfonic anhydride (206 μl) in dichloromethane (5 ml) was stirred at -20° C. under argon atmosphere for 5 min. To this solution the alcohol (7) (400 mg, 1.02 mmol) in dichloromethane (10 ml) was added and the mixture was stirred at room temperature for 40 min. The usual work-up (dichloromethane for extraction) gave the triflate (8) (612 mg), which was used in the next step without further purification. 1H-NMR δ: 0.73 (3H, s, 18-H3), 1.00 (3H, s, 19-H3), 1.15 (3H, d, J=6 Hz, 21-H3), 3.56 (2H, m, THP), 3.85 (1H, m, 3-H), 4.50 (2H, t, J=12 Hz, 24-H2), 4.70 (1H, m, THP), 5.37 (1H, m, 6-H). 19F-NMR δ: +12.2 (3F), +41.3 (2F).

Provenance & Evidence