Ethanol → HCID 54321600, compound

Participants

Reaction Steps

A mixture of 23.5 g of 1-dimethylamino-3-cyclopropyl-3-p-hydroxyphenoxy-propane, 100 ml of absolute ethanol and 200 ml of 0.5N ethanolic KOH is stirred for one hour at 20° and evaporated. The residue is dissolved in 250 ml of absolute DMF. 12.6 g of dimethyl sulphate is added in portions, with stirring. The mixture is boiled for two hours and evaporated; the residue is subjected to the customary working up; and 1-dimethylamino-3-cyclopropyl-3-p-methoxyphenoxy-propane is obtained.

Provenance & Evidence