Sulfuric Acid → 6-Methyl-1H-imidazo[1,2-b]pyrazole

HRID 615650Notes

Reaction equation

HRID 615650 reaction equation
C(O[CH:4](OCC)[CH2:5][N:6]1[C:10]([NH2:11])=[CH:9][C:8]([CH3:12])=[N:7]1)C.S(=O)(=O)(O)O.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH3:12][C:8]1[NH:7][N:6]2[CH:5]=[CH:4][N:11]=[C:10]2[CH:9]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 10340Sodium CarbonateHCID 10798646HCID 10798646, compound

Product 1

HCID 5431716-Methyl-1H-imidazo[1,2-b]pyrazoleYield 41%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The resultant (A) was heated in a mixture of 200 ml of ethanol and 80 ml of a 20% aqueous solution of sulfuric acid under reflux for 5 hours. After cooling, excess solid sodium carbonate was added thereto. The resulting mixture was filtered, and the solvent was removed from the filtrate. The thus obtained residue was recrystallized to provide 1.4 g of 6-methylimidazo[1,2-b]pyrazole. Yield was 41%.

Workup

  1. temperatureunder reflux for 5 hours
  2. temperatureAfter cooling
  3. filtrationThe resulting mixture was filtered
  4. customthe solvent was removed from the filtrate
  5. customThe thus obtained residue was recrystallized

Sources & evidence

ORD record
ord-f6538935e6c14af3ae91995a5ce6ee4a
Source dataset
uspto-grants-1985_02
Patent number
US04500630

Reaction notes

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