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L-Proline 1,1-dimethylethyl ester → H-Lys(Boc)-Pro-OtBu
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Proline 1,1-dimethylethyl ester | HCID 6453108 | — |
| 反応物 | N-(Nalpha-benzyloxycarbonyl-Nepsilon-tert-butoxycarbonyl-L-lysyl)-L-proline tert-butyl ester | HCID 14010667 | — |
| 触媒 | Palladium hydroxide | HCID 9942167 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | H-Lys(Boc)-Pro-OtBu | HCID 14010669 | — |
反応手順
A mixture of the 1,1-dimethylethyl ester product from part (a) (4.13 g., 7.73 mmole) and palladium hydroxide/carbon catalyst (400 mg.) in ethyl acetate (90 ml.) and ethanol (10 ml.) is stirred under a hydrogen atmosphere (balloon). The system is evacuated and refilled with fresh hydrogen every 30 minutes. After stirring for 3 hours, the catalyst is removed by filtration (Teflon millipore) and the filtrate is concentrated at reduced pressure to give 3.15 g. of 1-[N6 -](1,1-dimethylethoxy)carbonyl]-L-lysyl]-L-proline, 1,1-dimethylethyl ester as a colorless solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04500518 |
| 出典データセット | uspto-grants-1985_02 |
| ORD ID | ord-7ed0d1b9d377446eab25b71c6cdd91d2 |
| 出典メモ | uspto-grants-1985_02 |