Dicyclohexylcarbodiimide → HCID 53863859, compound

Participants

Reaction Steps

11.2 g (15.8 ml, 0.1 mol) of trimethylsilylethanol, 100 mg of 4-dimethylaminopyridine and 11.4 g of dicyclohexylcarbodiimide are added at room temperature to 7.9 g (0.05 mol) of 2-aminothiazol-4-ylacetic acid in 50 ml of acetonitrile and the mixture is stirred for 2 days. The precipitated urea is then filtered off under suction, washed with ether, the washings are concentrated on a rotary evaporator and the residue is taken up in ether and the ethereal solution is washed with 0.5N hydrochloric acid and with NaHCO3 solution, dried over MgSO4 and concentrated on a rotary evaporator. After concentration of the solution and addition of petroleum ether, the desired ester crystallizes out.

Provenance & Evidence