Acetic Anhydride → HCID 20426900, compound

Participants

Reaction Steps

To 1.0 g. of 4-(4-chlorophenyl)-2-(hydroxymethyl)-5H-pyrido[3,4-b][1,4]benzothiazin-3(2H)-one (2.8 mmol.) in 8 ml. of pyridine was added 4 ml. of acetic anhydride (42.3 mmol.), and the resulting suspension was stirred at room temperature for about 1 hour. The resulting solution was then concentrated under a nitrogen atmosphere, and the residue was titurated with methanol to yield a yellow precipitate which was washed with methanol and then air-dried to yield 4-(4-chlorophenyl)-2-[(acetyloxy)methyl]-5H-pyrido[3,4-b][1,4]-benzothiazin-3(2H)-one as a yellow solid (0.65 g; 58% yield) having the structural formula, ##STR12## a melting point in the range of 119°-120° C. and the following elemental analysis:

Provenance & Evidence